Mediterranean dried fruits are abundant in bioactive microconstituents, such as polar phenolics, which are credited for multiple beneficial health effects¹. Despite their low bioavailability, several studies have found a link between polar phenol ingestion and the ability to prevent neurodegeneration, decrease neuroinflammation, and improve cognitive performance^2,3. To better understand the mechanisms of action of polar phenolics, quantitative and qualitative data on their accumulation in the brain is critical. Hence, a simple, quick, and selective UPLC-Orbitrap MS method was implemented within the scope of the present study, aiming to investigate a wide range of polar phenols’ brain accumulation. This approach was successfully implemented to assess the deposition of polar phenols in brain tissue of rats that consumed a Mediterranean dried fruit. Our results indicate that polar phenolics present in the dried fruit, are in fact able to cross the blood-brain barrier (BBB) and accumulate in the brains of rats. Given that the brain distribution of polar phenolics is widely debated, our findings could be considered a stepping stone for further research to be conducted into the bioavailability and tissue specific distribution of bioactive phytochemicals associated with Mediterranean foods, such as dried fruits. The overall goal is to underline the merit of Mediterranean dried fruits of high nutritional value, for the promotion of a healthy brain, and ultimately the tissue-specific protection provided by foods rich in bioactive microconstituents.