In recent years, the losses of world agriculture from the damage of toxigenic microscopic fungi to grain crops alone and the accumulation of metabolites in them that are dangerous to humans and animals amount, according to various sources, from 2 to 16 billion dollars per year. Plant raw materials of food importance are affected by fungi of the genus Fusarium and are facultative parasites. Capable of further growth and intensive formation of mycotoxins under favorable conditions^1,2. In temperate zones of the globe, fusariotoxins – vomitoxin (deoxynivalenol), T-2 toxin and zearalenone are of the greatest sanitary importance in terms of frequency and prevalence^3,4. Zearalenone has estrogenic and teratogenic properties, as well as antibiotic action, therefore, poisoning with zearalenone leads to various disorders of the functions of various organs in the human and animal body^4,5. There are many developments on the effects on microbial communities to improve microbiocenosis in plant raw materials. Currently, the development of safe and effective biological drugs to combat toxigenic fungi is considered a promising direction in solving the problem. In order to obtain effective developments, it becomes important to study methods that determine their ability to inhibit the development of phytopathogens^6-9. The experiments were carried out on microscopic fungi of the genus Fusarium from the collection of museum strains of FGBI ‘FCTRB-VNIVI’. The indication of the mycotoxin zearalenone was carried out by thin-layer chromatography, enzyme immunoassay with confirmation of the results by high-performance liquid chromatography. The results of the studies showed that when growing the biomass of microscopic fungi Fusarium sporotrichioides, the use of a drug based on inorganic compounds inhibited the synthesis of zearalenone by 90% compared with the control group. Inhibition of the synthesis of mycotoxin zearalenone by microscopic fungi F. sporotrichioides when using a preparation based on microorganisms was 72% compared with the control parameters. The formation of the mycotoxin zearalenone by microscopic fungi F. sporotrichioides showed a significant decrease in the use of an organomineral-based drug by 95% compared with the control parameters. The results of the conducted research indicate that preparations of biological origin, as well as preparations based on organic and inorganic compounds, have various antagonistic properties against toxigenic micromycetes (F. sporotrichioides) and prevent their formation of toxic metabolites of mycotoxins (zearalenone) and can be selected to improve the sanitary properties and safety of food raw materials.

Acknowledgements:
The authors express their deep gratitude to Shamil Zavdatovich Validov (Research Institute ‘Laboratory of Molecular Genetic and Microbiological Methods’ FIT KAZNTS RAS), Eduard Iliаsovich Semenov, Rinat Salavatovich Mukhammadiev, Andrey Ivanovich Samsonov, Almaz Saubanovich Saifullin (Federal Center for Toxicological, Radiation and Biological Safety), Alexey Anatolyevich Nabatov (Department of Biochemistry of Kazan State Medical University), and Nikolai Ivanovich Budynkov (FGBNU ‘VNIIF’) for their help and valuable advice on conducting the analytical experiments.

Conflicts of interest:
The authors declare that they have no conflict of interest in the publication of this article. The authors have no conflicts of interest to report in this work. Abstract was not submitted elsewhere and was first published here.

Funding:
This study was supported by the Russian Science Foundation project 23-26-00161.