Introduction:
Intermittent fasting is one of the most popular trends for better health in recent years, helping modern people to get closer to biological situations that previously became familiar to them. It is a type of fasting that includes the feeding phase and the fasting phase that periodically alternates between them, forming the various shapes that even passed through the culture of peoples via religion such as Orthodox Christians, Muslims, and Adventists.

Methods:
Bibliographic systematic overview of scientific articles and books to evaluate fasting breaks in human health and well-being indicators using international scientific databases such as Pubmed, Scopus, Web of Science, Google Scholar and Google Trends.

Results:
Intermittent fasting is an example in the approach of weight loss and reduction of inflammation. Decreased insulin levels in combination with increased growth hormone secretion are the main reasons for its effectiveness as well as the release of catecholamines that promote fat burning. Oxidative stress and chronic inflammation are characteristic of the pathogenesis and progression of cancer and cardiovascular disease with a common risk factor of obesity. In this aspect, intermittent fasting activates cell signaling pathways by increasing antioxidant defense and DNA repair, by prolonging longevity and inhibiting the development of atherosclerotic plaque and by reducing the concentration of inflammatory markers such as IL-6 and CRP. It is generally a safe type of diet but also causes minimal unwanted neurological, hormonal and gastrointestinal effects.

Conclusions:
Intermittent fasting can be a factor in improving many health and wellness indicators by exerting a positive effect as an alternative diet model on the prevention of human diseases such as obesity, diabetes, cardiovascular and cancer. However, more extensive clinical trials are recommended to investigate which diet model is more effective for each group of people.