The efficacy of slow-release formulations of tribenuron-methyl (TBM) was compared with the efficacy of TBM as the active ingredient of the Mortira commercial formulation. The embedding of TBM into degradable matrix enabled long-duration functioning of this unstable herbicide in soil. The TBM formulations controlled the weeds considerably more effectively, with the biological efficacy of 95.7%, than the commercial formulation (52.2%). TBM was more effective against Amaranthus species, which were killed at an earlier stage, than against weeds of the Chenopodium album and the Galium aparine. Wheat yield was the highest in the case of the deposited herbicide 33.6*10² kg/ga and 32.5*10² kg/ga in the case of spraying crops with Mortira. The highest quality parameters (grain hectoliter mass, gluten and protein contents) were obtained in the group of plants treated with the embedded herbicide. The application of embedded TBM in field trials confirmed the high efficiency of the experimental formulation.