Dementia is a rising health problem that affects more than 50 million people worldwide. Current pharmacological options are unable to effectively treat dementia and can cause adverse effects. Secondary prevention of dementia has targeted pre-dementia stages such as Mild Cognitive Impairment (MCI). Natural Products have been suggested for the prevention of dementia and have shown promising results. We present key randomized clinical trials (RCT) of interventions with Natural Products in MCI and their neuroprotective properties. Pomegranate juice and its effects on memory and cognition has been studied in a double-blinded, placebo-controlled RCT with 200 participants aged 50-75 years with age related normal cognitive performance or MCI. The results showed statistically significant decline of visual memory in the placebo group whereas the intervention group maintained their cognitive abilities¹. Ellagic acid can be found in various vegetables, fruits, nuts, and berries, and has been shown to have anti-inflammatory, and antioxidant activity. Its neurocognitive properties have been studied in a double-blinded RCT with 150 male participants aged 45-55 years having normal weight or being overweight. Cognitive performance improved statistically significant in overweight participants consuming ellagic acid but no difference was observed in normal weight participants². Rosemary is known for its use in folk medicine. There are two clinical studies with promising results^3,4. Extra virgin olive oil was used in clinical trials for healthy elderly but also for patients with MCI with very good results in cognition⁵. Turmeric, baicalein, huperzine A, resveratrol, rifampicin, berberine, betaine, epigallocatechin-3-gallate, catechin, caffeine, docosahexaenoic acid, cinnamon, luteolin, bryostatin-1, ginger, genipin and saffron are used in clinical trials with different results. Perhaps Hippocrates saying that “our food is our medicine, and our medicine is our food” was right after all.