Cystic fibrosis (CF) is the most common genetically inherited disease among the Caucasian population. Achieving and maintaining of a good nutritional status is of vital importance as it has a great impact on improving lung function in these patients¹. Current guidelines² recommend children and adolescents with CF to achieve a BMI ≥50th percentile through a High-Fat, High-Calorie (HFHC) diet. Although most patients with CF are pancreatic insufficient (PI), approximately 15% of CF patients have pancreatic sufficiency (PS), due to mild CF mutation³. As PS patients are characterized by milder disease severity compared to PI ones, it is not known whether they have different dietary needs, if not lower. In the current presentation we will discuss about the overall nutritional support of patients with CF, based on the current guidelines. We will also focus on the existing evidence about the nutritional support, weight and metabolic profile of patients with PS. Based on recent epidemiological data, children and adolescents with PS seems to have better weight status and therefore better lung function compared to PI patients⁴. However, their metabolic status (e.g. fat and glucose levels) were worse compared to PI patients.